3'-Fluoro-3'-deoxythymidine
Cat. No.：YN482044
CAS No. ：25526-93-6
| 产品名称: | 3'-Fluoro-3'-deoxythymidine |
| CAS No.: | 25526-93-6 |
| Chemical Name: | 3'-deoxy-3'-fluoro-thymidine |
| Synonyms: | Alovudine |
| 分子量: | 244.22 |
| 分子式: | C₁₀H₁₃FN₂O₄ |
| SMILES: | OC[C@@H]1[C@@H](F)C[C@H](N2C(NC(C(C)=C2)=O)=O)O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3'-Fluoro-3'-deoxythymidine (Alovudine) 是 DNA 合成的标志物，其比18F-Fluorodeoxyglucose (FDG) 更不易受炎症变化的影响，因此在胰腺癌中是更好的生物标志物。 |
| IC50和靶点: | |
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Munch-Petersen, B., Cloos, L., Tyrsted, G., et al.Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosidesJ. Biol. Chem.266(14),9032-9038(1991)
Kong, X.-B., Zhu, Q.-Y., Vidal, P.M., et al.Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidineAntimicrob. Agents Chemother.36(4),808-818(1992)
Yehudai, D., Liyanage, S.U., Hurren, R., et al.The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemiaHaematologica104(5),963-972(2019)
Salskov, A., Tammisetti, V.S., Grierson, J., et al.FLT: measuring tumor cell proliferation in vivo with positron emission tomography and 3'-deoxy-3'-[18F]fluorothymidineSemin. Nucl. Med.37(6),429-439(2007)
