EGTA
Cat. No.：YN482260
| 产品名称: | EGTA |
| CAS No.: | 67-42-5 |
| Chemical Name: | 3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid |
| Synonyms: | Ethylenebis(oxyethylenenitrilo)tetraacet,乙二醇双(2-氨基乙基醚)四乙酸 |
| 分子量: | 380.35 |
| 分子式: | C₁₄H₂₄N₂O₁₀ |
| SMILES: | O=C(O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EGTA 是一种特殊的钙离子螯合剂。EGTA 在生理 pH 值 (7.4) 下，Kd为 60.5 nM，对 Ca2+比对 Mg2+有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Harafuji, H., and Ogawa, Y.Re-examination of the apparent binding constant of ethylene glycol bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid with calcium around neutral pHJ. Biochem.87(5),1305-1312(1980)
Jiang, S., Chow, S.C., Nicotera, P., et al.Intracellular Ca2+ signals activate apoptosis in thymocytes: Studies using the Ca2+-ATPase inhibitor thapsigarginExp. Cell. Res.212(1),84-92(1994)
Viswanath, D., Hedge, A.M., and Munshi, A.K.The removal of the smear layer using EGTA: A scanning electron microscopic studyJ. Clin. Pediatr. Dent.28(1),69-74(2003)
Gregory, L.G., Harbottle, R.P., Lawrence, L., et al.Enhancement of adenovirus-mediated gene transfer to the airways by DEAE dextran and sodium caprate in vivoMol. Ther.7(1),19-26(2003)
