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Direct Blue 1

Cat. No.:YN482279

  • CAS No. :2610-05-1

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    • 生物活性
    • 参考文献
    • 产品名称: Direct Blue 1
      CAS No.: 2610-05-1
      Chemical Name: 6,6′-[(3,3′-dimethoxy[1,1′-biphenyl]-4,4′-diyl)bis(2,1-diazenediyl)]bis[4-amino-5-hydroxy-1,3-naphthalenedisulfonic acid, tetrasodium salt
      Synonyms:Chicago Sky Blue 6B
      分子量:992.80
      分子式:C₃₄H₂₄N₆Na₄O₁₆S₄
      SMILES:COC1=CC(C2=CC=C(/N=N/C3=C(O)C4=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C4C=C3)C(OC)=C2)=CC=C1/N=N/C5=C(O)C6=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C6C=C5
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Direct Blue 1 (Chicago Sky Blue 6B) 是免疫荧光组织化学中背景自体荧光的一种复染料。Direct Blue 1 在结构上与谷氨酸盐有关,是一种有效且具有竞争性的VGLUT抑制剂,不影响质膜转运体。Direct Blue 1 是第一个能够抑制 Aβ 结合的小分子 PrP 配体。
      IC50和靶点:
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      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Roseth, S., Fykse, E.M., and Fonnum, F.Uptake of L-glutamate into rat brain synaptic vesicles: Effect of inhibitors that bind specifically to the glutamate transporterJ. Neurochem.65(1),96-103(1995)

      Sueyoshi, N., Takao, T., Nimura, T., et al.Inhibitors of the Ca2+/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N)Biochem. Biophys. Res. Commun.363(3),715-721(2007)

      Donkers, J.M., Zehnder, B., van Westen, G.J.P., et al.Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCPSci. Rep.7(1),15307(2017)

      Yu, G., Yi, S., Wang, M., et al.The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitorBehav. Pharmacol.24(8),653-658(2013)

      Cowen, T., Haven, A.J., and Burnstock, G.Pontamine sky blue: A counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistryHistochemistry82(3),205-208(1985)

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