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EGTA-AM

Cat. No.:YN482287

  • CAS No. :99590-86-0

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    • 参考文献
    • 产品名称: EGTA-AM
      CAS No.: 99590-86-0
      Chemical Name: 3,12-bis[2-[(acetyloxy)methoxy]-2-oxoethyl]-6,9-dioxa-3,12-diazatetradecanedioic acid, 1,14-bis[(acetyloxy)methyl] ester
      Synonyms:EGTA Acetoxymethyl ester
      分子量:668.60
      分子式:C₂₆H₄₀N₂O₁₈
      SMILES:O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)CCOCCOCCN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: EGTA-​AM 是 EGTA 的膜渗透形式,可以被动地载入到细胞中产生细胞内的 EGTA;EGTA-​AM 同时为 Ca2+螯合剂。
      IC50和靶点:
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      In Vivo:
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      Solvent & Solubility:
    • Drumm, B.T., Large, R.J., Hollywood, M.A., et al.The role of Ca2+ influx in spontaneous Ca2+ wave propagation in interstitial cells of Cajal from the rabbit urethraJ. Physiol.593(15),3333-3350(2015)

      Jalini, S., Ye, H., Tonkikh, A.A., et al.Raised intracellular calcium contributes to ischemia-induced depression of evoked synaptic transmissionPLoS One11(3),(2016)

      Nanou, E., Sullivan, J.M., Scheuer, T., et al.Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neuronsProc. Natl. Acad. Sci. USA113(4),1062-1067(2016)

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