6-Aminonicotinamide
Cat. No.：YN484341
| 产品名称: | 6-Aminonicotinamide |
| CAS No.: | 329-89-5 |
| Chemical Name: | 6-amino-3-pyridinecarboxamide |
| Synonyms: | 6-氨基烟酰胺 |
| 分子量: | 137.14 |
| 分子式: | C₆H₇N₃O |
| SMILES: | NC1=CC=C(C(N)=O)C=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 6-Aminonicotinamide，一种有效的烟酰胺抗代谢药，是竞争性 NADP+ 依赖性酶，葡萄糖 6-磷酸脱氢酶(G6PD)抑制剂 (Ki=0.46 μM)。 6-Aminonicotinamide 干扰糖酵解，导致 ATP 耗竭，并与 DNA 交联化学疗法药物，如Cisplatin，协同杀死癌细胞。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lange, K., and Proft, E.R.Inhibition of the 6-phosphogluconate dehydrogenase in the rat kidney by 6-aminonicotinamideNaunyn Schmiedebergs Arch. Pharmacol.267(2),177-180(1970)
Street, J.C., Alfieri, A.A., and Koutcher, J.A.Quantitation of metabolic and radiobiological effects of 6-aminonicotinamide in RIF-1 tumor cells in vitroCancer Res.57(18),3956-3962(1997)
Belfi, C.A., Chatterjee, S., Gosky, D.M., et al.Increased sensitivity of human colon cancer cells to DNA cross-linking agents after GRP78 up-regulationBiochem. Biophys. Res. Commun.257(2),361-368(1999)
Zuurbier, C.J., Eerbeek, O., Goedhart, P.T., et al.Inhibition of the pentose phosphate pathway decreases ischemia-reperfusion-induced creatine kinase release in the heartCardiovasc. Res.62(1),145-153(2004)
Penkowa, M., Quintana, A., Carrasco, J., et al.Metallothionein prevents nuerodegeneration and central nervous system cell death after treatment with gliotoxin 6-aminonicotinamideJ. Neurosci. Res.77(1),35-53(2004)
