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β-N-methylamino-L-alanine hydrochloride

Cat. No.:YN484393

  • CAS No. :16012-55-8

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    • 产品名称: β-N-methylamino-L-alanine hydrochloride
      CAS No.: 16012-55-8
      Chemical Name: 3-(methylamino)-L-alanine, monohydrochloride
      Synonyms:BMAA hydrochloride
      分子量:154.60
      分子式:C₄H₁₁ClN₂O₂
      SMILES:N[C@@H](CNC)C(O)=O.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: β-N-methylamino-L-alanine hydrochloride (BMAA hydrochloride) 是一种蓝细菌产生的神经毒素,可能导致肌萎缩性侧索硬化症 (ALS) 以及其他可能的神经退行性疾病。
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    • Holtcamp, W.The emerging science of BMAA: Do cyanobacteria contribute to neurodegenerative disease?Environ. Health Perspect.120(3),A110-A116(2012)

      Chiu, A.S., Gehringer, M.M., Welch, J.H., et al.Does α-amino-β-methylaminopropionic acid (BMAA) play a role in neurodegeneration?Int. J. Environ. Res. Public Health8(9),3728-3746(2011)

      Lobner, D., Piana, P.M.T., Salous, A.K., et al.β-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanismsNeurobiol. Dis.25(2),360-366(2007)

      Liu, X., Rush, T., Zapata, J., et al.β-N-methylamino-L-alanine induces oxidative stress and glutamate release through action on system Xc¯Exp. Neurol.217(2),429-433(2009)

      Matsuoka, Y., Rakonczay, Z., Giacobini, E., et al.L-β-methylamino-alanine-induced behavioral changes in ratsPharmacol. Biochem. Behav.44(3),727-734(1993)

      Spencer, P.S., Nunn, P.B., Hugon, J., et al.Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxinScience237(4814),517-522(1987)

      Jiang, L., Kiselova, N., Rosén, J., et al.Quantification of neurotoxin BMAA (β-N-methylamino-L-alanine) in seafood from Swedish marketsSci. Rep.4,6931(2014)

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