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(-)-Isocorypalmine

Cat. No.:YN1740007

  • CAS No. :483-34-1

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    • 参考文献
    • 产品名称: (-)-Isocorypalmine
      CAS No.: 483-34-1
      Chemical Name: (13aS)-5,8,13,13a-tetrahydro-3,9,10-trimethoxy-6H-dibenzo[a,g]quinolizin-2-ol
      Synonyms:Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine
      分子量:341.40
      分子式:C₂₀H₂₃NO₄
      SMILES:OC(C=C1[C@@]2([H])N3CC4=C(C=CC(OC)=C4OC)C2)=C(C=C1CC3)OC
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: (-)-Isocorypalmine (Tetrahydrocolumbamine) 是从延胡索粗碱中分离得到的多巴胺受体 (dopamine receptor) 配体。重组CYP719A21 对 (-)-Isocorypalmine 具有严格的底物特异性和高亲和力 (Km=4.63 μM)。
      IC50和靶点:
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    • Xiao, W., Zhuang, X., Shen, G., et al.Simultaneous quantification of ?-tetrahydropalmatine and its urine metabolites by ultra high performance liquid chromatography with tandem mass spectrometryJ. Sep. Sci.37(6),696-703(2014)

      Lee, D.Y.W., Liu, J., Zhang, S., et al.Asymmetric total synthesis of tetrahydroprotoberberine derivatives andevaluation of their binding affinities at dopamine receptorsBioorg. Med. Chem. Lett.27(6),1437-1440(2017)

      Ito, C., Itoigawa, M., Tokuda, H., et al.Chemopreventive activity of isoquinoline alkaloids from Corydalis plantsPlanta Med.67(5),473-475(2001)

      Kim, K.H., Piao, C., J., Choi, S.U., et al.New cytotoxic tetrahydroprotoberberine-aporphine dimeric and aporphine alkaloids from Corydalis turtschaninoviiPlanta Med.76(15),1732-1738(2010)

      Rao, G.-X., Zhang, S., Wang, H.-M., et al.Antifungal alkaloids from the fresh rattan stem of Fibraurea recisa PierreJ. Ethnopharmacol.123(1),1-5(2009)

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