PF-998425
Cat. No.：YN470045
| 产品名称: | PF-998425 |
| CAS No.: | 1076225-27-8 |
| Chemical Name: | 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl)-benzonitrile |
| Synonyms: | PF0998425; PF 0998425; PF-0998425. |
| 分子量: | 269.2623096 |
| 分子式: | C14H14F3NO |
| SMILES: | O[C@H]1[C@@H](C2=CC(C(F)(F)F)=C(C#N)C=C2)CCCC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-998425 是一种有效的选择性非甾体雄激素受体 (androgen receptor) 拮抗剂，在 AR 结合和细胞分析中的IC50分别为 37 nM 和 43 nM。PF-998425 对常见受体和酶 (如孕酮受体) 的活性较低。PF-998425 可用于皮脂控制和雄激素性脱发的研究。 |
| IC50和靶点: | |
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Li, J.J., Iula, D.M., Nguyen, M.N., et al.Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indicationsJ. Med. Chem.51(21),7010-7014(2008)
