Lasofoxifene
Cat. No.:YN470051
产品名称: | Lasofoxifene |
CAS No.: | 180916-16-9 |
Chemical Name: | (5R,6S)-5,6,7,8-tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol |
Synonyms: | 拉索昔芬; CP-336156 |
分子量: | 413.6 |
分子式: | C28H31NO2 |
SMILES: | OC(C=C1)=CC2=C1[C@@H](C3=CC=C(OCCN4CCCC4)C=C3)[C@@H](C5=CC=CC=C5)CC2 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Lasofoxifene (CP-336156) 是一种具有口服活性和选择性的雌激素受体调节剂 (SERM)。Lasofoxifene 具有抗骨质疏松的功能,还能抑制原生肿瘤生长和转移。Lasofoxifene 可用于乳腺癌和绝经后骨质疏松症的研究。 |
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Ke, H.Z., Paralkar, V.M., Grasser, W.A., et al.Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus, and body composition in rat modelsEndocrinology139(4),2068-2076(1998)
Cummings, S.R., Ensrud, K., Delmas, P.D., et al.Lasofoxifene in postmenopausal women with osteoporosisN. Engl. J. Med.362(8),686-696(2010)
Gennari, L., Merlotti, D., and Nuti, R.Selective estrogen receptor modulator (SERM) for the treatment of osteoporosis in postmenopausal women: Focus on lasofoxifeneClin. Interv. Aging5,19-29(2010)
Kumar, P., and Song, Z.H.CB2 cannabinoid receptor is a novel target for third-generation selective estrogen receptor modulators bazedoxifene and lasofoxifeneBiochem. Bioph. Res. Commun.443(1),144-149(2014)