Debutyldronedarone hydrochloride
Cat. No.：YN470052
| 产品名称: | Debutyldronedarone hydrochloride |
| CAS No.: | 197431-02-0 |
| Chemical Name: | N-[2-butyl-3-[4-[3-(butylamino)propoxy]benzoyl]-5-benzofuranyl]-methanesulfonamide, monohydrochloride |
| Synonyms: | SR35021 hydrochloride |
| 分子量: | 537.11186 |
| 分子式: | C27H36N2O5S • HCl |
| SMILES: | O=C(C1=C(CCCC)OC2=CC=C(NS(C)(=O)=O)C=C21)C3=CC=C(C=C3)OCCCNCCCC.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Debutyldronedarone (SR35021) hydrochloride 是 Dronedarone 的主要代谢物，是一种选择性的甲状腺激素受体 α1(TRα1) 抑制剂。Debutyldronedarone hydrochloride 抑制 T3 与 TRα1和TRβ1的结合，抑制率分别为 77% 和 25%。Debutyldronedarone hydrochloride 可用于心律失常的研究。 |
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Van Beeren, H.C., Jong, W.M.C., Kaptein, E., et al.Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-α1: in vitro and in vivo evidenceEndocrinology144(2),552-558(2003)
Karkhanis, A., Tram, N.D.T., and Chan, E.C.Y.Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acidsBiochem. Pharmacol.146,188-198(2017)
Karkhanis, A., Leow, J.W.H., Hagen, T., et al.Dronedarone-induced cardiac mitochondrial dysfunction and its mitigation by epoxyeicosatrienoic acidsToxicol. Sci.163(1),79-91(2018)
Klieber, S., Arabeyre-Fabre, C., Moliner, P., et al.Identification of metabolic pathways and enzyme systems involved in the in vitro human hepatic metabolism of dronedarone, a potent new oral antiarrhythmic drugPharmacol. Res. Perspec.2(3),e00044(2014)
