Elocalcitol
Cat. No.：YN470053
| 产品名称: | Elocalcitol |
| CAS No.: | 199798-84-0 |
| Chemical Name: | (1R,3Z,5S)-3-[(2E)-2-[(3aS,7aS)-1-[(1S,3E)-5-ethyl-5-hydroxy-1-methyl-3-hepten-1-yl]-3,3a,5,6,7,7a-hexahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylene-cyclohexanol |
| Synonyms: | 异地糖醇; BXL-628; Ro-26-9228 |
| 分子量: | 442.7 |
| 分子式: | C29H43FO2 |
| SMILES: | C[C@@]12[C@](CC=C2[C@@H](C)C/C=C/C(CC)(O)CC)([H])/C(CCC1)=C/C=C3C[C@@H](O)C[C@H](F)C/3=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Elocalcitol (BXL-628) 是一种选择性的、具有口服活性的vitamin D receptor (VDR)激动剂。Elocalcitol 具有抗炎活性。Elocalcitol 抑制前列腺癌细胞的生长。 |
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Crescioli, C., Ferruzzi, P., Caporali, A., et al.Inhibition of prostate cell growth by BXL-628, a calcitriol analogue selected for a phase II clinical trial in patients with benign prostate hyperplasiaEur. J. Endocrinol.150(4),591-603(2004)
Benigni, F., Baroni, E., Zecevic, M., et al.Oral treatment with a vitamin D3 analogue (BXL628) has anti-inflammatory effects in rodent model of interstitial cystitisBJU Int.97(3),617-624(2006)
Mariani, M., Viganò, P., Gentilini, D., et al.The selective vitamin D receptor agonist, elocalcitol, reduces endometriosis development in a mouse model by inhibiting peritoneal inflammationHum. Reprod.27(7),2010-2019(2012)
