Hydroxyflutamide
Cat. No.：YN470066
CAS No. ：52806-53-8
| 产品名称: | Hydroxyflutamide |
| CAS No.: | 52806-53-8 |
| Chemical Name: | 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide |
| Synonyms: | HFT |
| 分子量: | 292.2 |
| 分子式: | C11H11F3N2O4 |
| SMILES: | O=C(C(O)(C)C)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Hydroxyflutamide (HF)，Flutamide 的活性代谢物，是一种有效的雄激素受体 (androgen receptor) 拮抗剂 (IC50=700 nM)。Hydroxyflutamide 可用于前列腺癌的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Shet, M.S., McPhaul, M., Fisher, C.W., et al.Metabolism of the antiandrogenic drug (flutamide) by human CYP1A2Drug Metab. Dispos.25(11),1298-1303(1997)
Kolvenbag, G.J.C.M., Furr, B.J.A., and Blackledge, G.R.P.Receptor affinity and potency of non-steroidal antiandrogens: Translation of preclinical findings into clinical activityProstate Cancer Prostatic Dis.1(6),307-314(1998)
Gao, W., Kim, J., and Dalton, J.T.Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligandsPharmacol. Res.23(8),1641-1658(2006)
