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Reverse T3

Cat. No.:YN470068

  • CAS No. :5817-39-0

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Reverse T3
      CAS No.: 5817-39-0
      Chemical Name: O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine
      Synonyms:3′,5′,3-Triiodothyronine
      分子量:651
      分子式:C15H12I3NO4
      SMILES:IC1=C(O)C(I)=CC(OC2=CC=C(C[C@H](N)C(O)=O)C=C2I)=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Reverse T3 是一种由甲状腺素原脱碘产生的甲状腺激素。Reverse T3 抑制新生大鼠心肌细胞中由其它甲状腺激素类似物引起的钠电流增加。
      IC50和靶点:
      In Vitro:
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    • Collingwood, T.N., Sydenham, M., Page, M.J., et al.Functional properties of human thyroid hormone receptor β1 overexpressed using baculovirusFEBS Lett.291(2),315-318(1991)

      Koury, E.J., Pawlyk, A.C., Berrodin, T.J., et al.Characterization of ligands for thyroid receptor subtypes and their interactions with co-regulatorsSteroids74(2),270-276(2009)

      Tien, E.S., Matsui, K., Moore, R., et al.The nuclear receptor constitutively active/androstane receptor regulates type 1 deiodinase and thyroid hormone activity in the regenerating mouse liverJ. Pharmacol. Exp. Ther.320(1),307-313(2007)

      Ohguchi, H., Tanaka, T., Uchida, A., et al.Hepatocyte nuclear factor 4α contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Krüppel-like transcription factor 9Mol. Cell. Biol.28(12),3917-3931(2008)

      Economidou, F., Douka, E., Tzanela, M., et al.Thyroid function during critical illnessHormones10(2),117-124(2011)

      Novitzky, D., and Cooper, D.K.C.Thyroid hormone and the stunned myocardiumJ. Endocrinol.223(1),R1-R8(2014)

      Senese, R., Cioffi, F., de Lange, P., et al.Thyroid: Biological actions of 'nonclassical' thyroid hormonesJ. Endocrinol.221(2),R1-R12(2014)

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      C2
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