4'-Hydroxytamoxifen
Cat. No.：YN470071
| 产品名称: | 4'-Hydroxytamoxifen |
| CAS No.: | 82413-23-8 |
| Chemical Name: | 4-[(1Z)-1-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]-phenol |
| Synonyms: | |
| 分子量: | 387.5 |
| 分子式: | C26H29NO2 |
| SMILES: | CC/C(C1=CC=C(O)C=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 4'-Hydroxytamoxifen 是 Tamoxifen 的代谢物。4'-Hydroxytamoxifen 对ER的亲和力高于 Tamoxifen。4'-Hydroxytamoxifen 在人子宫内膜腺癌细胞中诱导非凋亡细胞毒性。 |
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Crewe, H.K., Notley, L.M., Wunsch, R.M., et al.Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: Formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifenDrug Metab. Dispos.30(8),869-874(2002)
Desta, Z., Ward, B.A., Soukhova, N.V., et al.Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6J. Pharmacol. Exp. Ther.310(3),1062-1075(2004)
Dahmane, E., Boccard, J., Csajka, C., et al.Quantitative monitoring of tamoxifen in human plasma extended to 40 metabolites using liquid-chromatography high-resolution mass spectrometry: New investigation capabilities for clinical pharmacologyAnal. Bioanal. Chem.406(11),2627-2640(2016)
Ruenitz, P.C., Bagley, J.R., and Mokler, C.M.Estrogenic and antiestrogenic activity of monophenolic analogues of tamoxifen, (Z)-2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N, N-dimethylethylamineJ. Med. Chem.25(9),1056-1060(1982)
Cuevas, M.E., and Lindeman, T.E.In vitro cytotoxicity of 4'-OH-tamoxifen and estradiol in human endometrial adenocarcinoma cells HEC-1A and HEC-1BOncol. Rep.33(1),464-470(2016)
