Estrogen receptor antagonist 7
Cat. No.：YN470093
| 产品名称: | Estrogen receptor antagonist 7 |
| CAS No.: | 849662-80-2 |
| Chemical Name: | |
| Synonyms: | [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]methanone;Y 134;AGN-PC-00G3TZ;CHEMBL178334;CTK8F1074;CHEBI:401584;HMS3269L21 |
| 分子量: | 472.59852 |
| 分子式: | C28H28N2O3S |
| SMILES: | OC1C=CC2C(C(C3C=CC(N4CCN(C(C)C)CC4)=CC=3)=O)=C(C3C=CC(O)=CC=3)SC=2C=1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Y134 是一种选择性和具有口服活性的雌激素受体 (ER) 调节剂 (SERM)，对ERα和ERβ表现出强效拮抗剂活性。Y134 对ERα(Ki=0.09 nM) 的选择性比对ERβ(Ki=11.31 nM) 高 121.1 倍。Y134 抑制雌激素刺激的 ER 阳性人乳腺癌细胞的增殖。 |
| IC50和靶点: | [{name:"ERα:0.09 nM (Ki)"},{name: "ERβ:11.31 nM (Ki)"}] |
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