(2R)-Octyl-α-hydroxyglutarate
Cat. No.:YN480253
CAS No. :1391194-67-4
产品名称: | (2R)-Octyl-α-hydroxyglutarate |
CAS No.: | 1391194-67-4 |
Chemical Name: | 2R-hydroxy-pentanedioic acid, 1-octyl ester |
Synonyms: | (2R)-Octyl-2-HG |
分子量: | 260.33 |
分子式: | C₁₃H₂₄O₅ |
SMILES: | O=C(OCCCCCCCC)[C@H](O)CCC(O)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | (2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) 是2-Hydroxyglutarate 的D型异构体的修饰物。 |
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Struys, E.A., Verhoeven, N.M., Roos, B., et al.Disease-related metabolites in culture medium of fibroblasts from patients with D-2-hydroxyglutaric aciduria, L-2-hydroxyglutaric aciduria, and combined D/L-2-hydroxyglutaric aciduriaClin. Chem.49(7),1133-1138(2003)
Struys, E.A., Salomons, G.S., Achouri, Y., et al.Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduriaAm. J. Hum. Genet.76(2),358-360(2005)
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Chowdhury, R., Yeoh, K.K., Tian, Y.M., et al.The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylasesEMBO Rep.12(5),463-469(2011)
Reitman, Z.J., Duncan, C.G., Poteet, E., et al.Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxiaJ. Biol. Chem.289(34),23318-23328(2014)