10-Deacetylbaccatin III
Cat. No.:YN481546
CAS No. :32981-86-5
产品名称: | 10-Deacetylbaccatin III |
CAS No.: | 32981-86-5 |
Chemical Name: | (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one |
Synonyms: | 10-脱乙酰巴卡丁 III,10-脱乙酰基巴卡丁III |
分子量: | 544.59 |
分子式: | C₂₉H₃₆O₁₀ |
SMILES: | CC1=C([C@@H](O)C([C@@]2(C)[C@@]3([H])[C@@](CO4)(OC(C)=O)[C@@]4([H])C[C@@H]2O)=O)C(C)(C)[C@@]([C@H]3OC(C5=CC=CC=C5)=O)(O)C[C@@H]1O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | 10-Deacetylbaccatin-III是紫杉醇制备过程中的中间体。 |
IC50和靶点: | |
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Lataste, H., Senilh, V., Wright, M., et al.Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubulesProc. Natl. Acad. Sci. USA81(13),4090-4094(1984)
Zhiri, A., Jaziri, M., Guo, Y., et al.Tissue cultures of Taxus baccata as a source of 10-deacetylbaccatin III, a precursor for the hemisynthesis of taxolBiol. Chem. Hoppe Seyler376(10),583-586(1995)
Georgopoulou, K., Smirlis, D., Bisti, S., et al.In vitro activity of 10-deacetylbaccatin III against Leishmania donovani promastigotes and intracellular amastigotesPlanta Med.73(10),1081-1088(2007)