13-Methylberberine chloride
Cat. No.：YN480842
| 产品名称: | 13-Methylberberine chloride |
| CAS No.: | 54260-72-9 |
| Chemical Name: | 5,6-dihydro-9,10-dimethoxy-13-methyl-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, monochloride |
| Synonyms: | 13-Methylberberinium chloride |
| 分子量: | 385.84 |
| 分子式: | C₂₁H₂₀ClNO₄ |
| SMILES: | CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OCO5)=C5C=C4CC3.[Cl-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 13-Methylberberine chloride (13-Methylberberinium chloride)，黄连素类似物，具有抗脂肪和抗肿瘤活性。13-Methylberberine chloride (13-Methylberberinium chloride) 可增加 IL-12 的产生，并在 LPS 激活的巨噬细胞转录后抑制 iNOS 的表达。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Chow, Y.-L., Sogame, M., and Sato, F.13-Methylberberine, a berberine analogue with stronger anti-adipogenic effects on mouse 3T3-L1 cellsSci. Rep.6,38129(2016)
Kong, W., Wei, J., Abidi, P., et al.Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statinsNat. Med.10(12),1344-1351(2004)
Iwasa, K., Kamigauchi, M., Ueki, M., et al.Antibacterial activity and structure-activity relationships of berberine analogsEur. J. Med. Chem.31(6),469-478(1996)
Iwasa, K., Moriyasu, M., Yamori, T., et al.In vitro cytotoxicity of the protoberberine-type alkaloidsJ. Nat. Prod.64(7),896-898(2001)
Lee, D.U., Kang, Y.J., Park, M.K., et al.Effects of 13-alkyl-substituted berberine alkaloids on the expression of COX-II, TNF-α, iNOS, and IL-12 production in LPS-stimulated macrophagesLife Sci.73(11),1401-1412(2003)
