CBR-5884
Cat. No.:YN480002
产品名称: | CBR-5884 |
CAS No.: | 681159-27-3 |
Chemical Name: | 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylic acid, ethyl ester |
Synonyms: | 5-[(2-Furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylic acid ethyl ester;CBR 5884;CBR-5884 |
分子量: | 336.39 |
分子式: | C₁₄H₁₂N₂O₄S₂ |
SMILES: | O=C(C1=C(C)C(SC#N)=C(NC(C2=CC=CO2)=O)S1)OCC |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | CBR-5884 是一种有效,选择性的磷酸甘油酸脱氢酶 (PHGDH)抑制剂,IC50为 33 μM。 CBR-5884 抑制癌细胞中的丝氨酸合成,并且对具有高丝氨酸生物合成活性的癌细胞系具有选择性毒性。 CBR-5884 选择性地抑制黑素瘤和乳腺癌细胞系的增殖。 |
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Mullarky, E., Lucki, N.C., Zavareh, R.B., et al.Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancersProc. Natl. Acad. Sci. USA113(7),1778-1783(2016)