Sufugolix
Cat. No.：YN480030
CAS No. ：308831-61-0
规格
价格(RMB)
库存
| 产品名称: | Sufugolix |
| CAS No.: | 308831-61-0 |
| Chemical Name: | N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[methyl(phenylmethyl)amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy-urea |
| Synonyms: | TAK-013 |
| 分子量: | 667.72 |
| 分子式: | C₃₆H₃₁F₂N₅O₄S |
| SMILES: | O=C(NOC)NC1=CC=C(C(S2)=C(CN(C)CC3=CC=CC=C3)C(C(N4C5=CC=CC=C5)=O)=C2N(CC6=C(F)C=CC=C6F)C4=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sufugolix (TAK-013)高效有口服活性的黄体激素释放激素 (LHRH) 受体拮抗剂，IC50值为0.1 nM。 |
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Sasaki, S., Cho, N., Nara, Y., et al.Discovery of a thieno[2,3-d]pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: A highly potent and orally bioavailable non-peptide antagonist for the human luteinizing hormone-releasing hormone receptorJ. Med. Chem.46(1),113-124(2003)
Hara, T., Araki, H., Kusaka, M., et al.Suppression of a pituitary-ovarian axis by chronic oral administration of a novel nonpeptide gonadotropin-releasing hormone antagonist, TAK-013, in cynomolgus monkeysJ. Clin. Endocrinol. Metab.88(4),1697-1704(2003)
