M2I-1
Cat. No.：YN480054
CAS No. ：312271-03-7
规格
价格(RMB)
库存
| 产品名称: | M2I-1 |
| CAS No.: | 312271-03-7 |
| Chemical Name: | 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione |
| Synonyms: | M2I 1 |
| 分子量: | 404.48 |
| 分子式: | C₁₉H₂₄N₄O₄S |
| SMILES: | O=C(/C(C(N1)=O)=C\C2=CC=C(N(CC(C)C)CC(C)C)C([N+]([O-])=O)=C2)NC1=S |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | M2I-1 是一种Mad2抑制剂，靶向 Mad2 与 Cdc20 的结合，Mad2 与 Cdc20 结合是纺锤体装配检查点 (SAC) 内必不可少的蛋白-蛋白相互作用 (PPI)。 |
| IC50和靶点: | |
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Kastl, J., Braun, J., Prestel, A., et al.Mad2 inhibitor-1 (M2I-1): A small molecule protein-protein interaction inhibitor targeting the mitotic spindle assembly checkpointACS Chem. Biol.10(7),1661-1666(2015)
Huang, Y., Ha, S., Li, Z., et al.CHK1-CENP B/MAD2 is associated with mild oxidative damage-induced sex chromosome aneuploidy of male mouse embryos during in vitro fertilizationFree Radic. Biol. Med.137,181-193(2019)
