CCF642
Cat. No.：YN480061
CAS No. ：346640-08-2
规格
价格(RMB)
库存
| 产品名称: | CCF642 |
| CAS No.: | 346640-08-2 |
| Chemical Name: | 3-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone |
| Synonyms: | AC1LYELL |
| 分子量: | 378.45 |
| 分子式: | C₁₅H₁₀N₂O₄S₃ |
| SMILES: | O=C1N(C2=CC=C(OC)C=C2)C(S/C1=C/C3=CC=C([N+]([O-])=O)S3)=S |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CCF642 是一种有效的蛋白质二硫键异构酶 (PDI) 抑制剂，IC50为 2.9 μM。CCF642 在多发性骨髓瘤细胞中引起急性内质网 (ER) 应激，并伴随凋亡诱导的钙释放。CCF642 具有广泛的抗多发性骨髓瘤活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Vatolin, S., Phillips, J.G., Jha, B.K., et al.Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myelomaCancer Res.76(11),3340-3350(2016)
