Paquinimod
Cat. No.：YN480064
CAS No. ：248282-01-1
规格
价格(RMB)
库存
| 产品名称: | Paquinimod |
| CAS No.: | 248282-01-1 |
| Chemical Name: | N,5-diethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide |
| Synonyms: | 帕奎莫德; ABR 25757 |
| 分子量: | 350.41 |
| 分子式: | C₂₁H₂₂N₂O₃ |
| SMILES: | O=C(C1=C(O)C2=C(C=CC=C2CC)N(C)C1=O)N(CC)C3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Paquinimod 是一种S100A9抑制剂，阻止 S100A9 与TLR-4结合。 |
| IC50和靶点: | |
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Helmersson, S., Sundstedt, A., Deronic, A., et al.Amelioration of experimental autoimmune encephalomyelitis by the quinoline-3-carboxamide paquinimod: Reduced priming of proinflammatory effector CD4+ T cellsAm. J. Pathol.182(5),1671-1680(2013)
Fransén Pettersson, N., Deronic, A., Hannibal, T.D., et al.The immunomodulatory quinoline-3-carboxamide paquinimod reverses established fibrosis in a novel mouse model for liver fibrosisPLoS One13(9),e0203228(2018)
Tahvili, S., Törngren, M., Holmberg, D., et al.Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mousePLoS One13(5),e0196598(2018)
Stenström, M., Nyhlén, H.C., Törngren, M., et al.Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosisJ. Dermatol. Sci.83(1),52-59(2016)
