URB602
Cat. No.：YN480089
CAS No. ：565460-15-3
规格
价格(RMB)
库存
| 产品名称: | URB602 |
| CAS No.: | 565460-15-3 |
| Chemical Name: | N-[1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester |
| Synonyms: | URB 602,URB-602 |
| 分子量: | 295.38 |
| 分子式: | C₁₉H₂₁NO₂ |
| SMILES: | O=C(OC1CCCCC1)NC2=CC(C3=CC=CC=C3)=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | URB602 是一种选择性的单酰基甘油脂肪酶 (MGL) 抑制剂，非竞争性抑制大鼠脑 MGL，IC50为 28±4 μM。 |
| IC50和靶点: | |
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Hohmann, A.G., Suplita, R.L., Bolton, N.M., et al.An endocannabinoid mechanism for stress-induced analgesiaNature435,1108-1112(2005)
Tarzia, G., Duranti, A., Tontini, A., et al.Design, Synthesis, and strcture-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitorsJ. Med. Chem.46,2352-2360(2003)
Berdan, C.S., Erion, K.A., Burritt, N.E., et al.Inhibition of monoacylglycerol lipase activity decreases glucose-stimulated insulin secretion in INS-1 (832/13) cells and rat isletsPLoS One11(2),e0149008(2016)
