OGT 2115
Cat. No.：YN480094
CAS No. ：853929-59-6
规格
价格(RMB)
库存
| 产品名称: | OGT 2115 |
| CAS No.: | 853929-59-6 |
| Chemical Name: | 2-[4-[[3-(4-bromophenyl)-1-oxo-2-propen-1-yl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid |
| Synonyms: | |
| 分子量: | 495.30 |
| 分子式: | C₂₄H₁₆BrFN₂O₄ |
| SMILES: | O=C(O)CC1=CC=C(OC(C2=CC=C(NC(/C=C/C3=CC=C(Br)C=C3)=O)C(F)=C2)=N4)C4=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | OGT 2115 是一种有效的，细胞可渗透且口服活性的乙酰肝素酶 (heparanase) 抑制剂，IC50为 0.4 μM。OGT 2115 具有抗血管生成特性 (IC50为 1 μM)。OGT 2115 还抑制硫酸乙酰肝素的降解活性。 |
| IC50和靶点: | |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Courtney, S.M., Hay, P.A., Buck, R.T., et al.Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: Novel classes of heparanase inhibitorBioorg. Med. Chem. Lett.15(9),2295-2299(2005)
Nishimura, Y., Shitara, E., Adachi, H., et al.Flexible synthesis and biological activity of uronic acid-type gem-diamine 1-N-iminosugars: A new family of glycosidase inhibitorsJ. Org. Chem.65(1),2-11(2000)
Hopkins, J., Yadavalli, T., Agelidis, A.M., et al.Host enzymes heparanase and cathepsin L promote herpes simplex virus 2 release from cellsJ. Virol.92(23),e01179-e01218(2018)
