OSW-1
Cat. No.：YN480105
CAS No. ：145075-81-6
规格
价格(RMB)
库存
| 产品名称: | OSW-1 |
| CAS No.: | 145075-81-6 |
| Chemical Name: | (3β,16β)-16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxy-cholest-5-en-22-one |
| Synonyms: | OSW1 |
| 分子量: | 873.03 |
| 分子式: | C₄₇H₆₈O₁₅ |
| SMILES: | C[C@@]1([C@@]2(O)[C@H](C)C(CCC(C)C)=O)[C@](C[C@@H]2O[C@@](OC[C@H](O)[C@@H]3O[C@@](OC[C@@H](O)[C@@H]4O)([H])[C@@H]4OC(C5=CC=C(OC)C=C5)=O)([H])[C@@H]3OC(C)=O)([H])[C@@](CC=C6[C@@]7(CC[C@H](O)C6)C)([H])[C@]7([H])CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | OSW-1 是从虎眼万年青中分离出来的，osterol-binding protein (OSBP)和OSBP-elated protein 4 (ORP4)的特异性拮抗剂，其在人类肿瘤细胞系中的GI50值为纳摩尔级别。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Mimaki, Y., Kuroda, M., Kameyama, A., et al.Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbsBioorg. Med. Chem. Lett.7(5),633-636(1997)
Roberts, B.L., Severance, Z.C., Bensen, R.C., et al.Differing activities of oxysterol-binding protein (OSBP) targeting anti-viral compoundsAntiviral Res.170:104548,(2019)
Burgett, A.W.G., Poulsen, T.B., Wangkanont, K., et al.Natural products reveal cancer cell dependence on oxysterol-binding proteinsNat. Chem. Biol.7(9),639-647(2011)
Albulescu, L., Strating, J.R., Thibaut, H.J., et al.Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBPAntiviral Res.117,110-114(2015)
Strating, J.R.P.M., van der Linden, L., Albulescu, L., et al.Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding proteinCell Rep.10(4),600-615(2015)
