LY 345899
Cat. No.：YN480213
CAS No. ：10538-99-5
规格
价格(RMB)
库存
| 产品名称: | LY 345899 |
| CAS No.: | 10538-99-5 |
| Chemical Name: | N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1,9-dioxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutamic acid |
| Synonyms: | LY345899;LY 345899 |
| 分子量: | 471.42 |
| 分子式: | C₂₀H₂₁N₇O₇ |
| SMILES: | O=C(O)[C@@H](NC(C1=CC=C(N2C(N3C4=C(NC(N)=NC4=O)NCC3C2)=O)C=C1)=O)CCC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY 345899 是一种叶酸的类似物，也是一种亚甲基四氢叶酸脱氢酶 (MTHFD1;DC301) 和MTHFD2抑制剂，其IC50值分别为 96 nM 和 663 nM，对MTHFD1的Ki值为 18 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Gustafsson, R., Jemth, A.-S., Gustafsson, N.M.S., et al.Crystal structure of the emerging cancer target MTHFD2 in complex with a substrate-based inhibitorCancer Res.77(4),937-948(2017)
Ju, H.-Q., Lu, Y.-X., Chen, D.-L., et al.Modulation of redox homeostasis by inhibition of MTHFD2 in colorectal cancer: Mechanisms and therapeutic implicationsJ. Natl. Cancer Inst.111(6),584-596(2109)
