RG3039
Cat. No.：YN480219
CAS No. ：1005504-62-0
规格
价格(RMB)
库存
| 产品名称: | RG3039 |
| CAS No.: | 1005504-62-0 |
| Chemical Name: | 5-[[1-[(2,6-dichlorophenyl)methyl]-4-piperidinyl]methoxy]-2,4-quinazolinediamine |
| Synonyms: | PF-06687859 |
| 分子量: | 432.35 |
| 分子式: | C₂₁H₂₃Cl₂N₅O |
| SMILES: | NC1=NC(N)=C2C(OCC3CCN(CC4=C(Cl)C=CC=C4Cl)CC3)=CC=CC2=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RG3039 (PF-06687859) 是具有口服活性，可渗透大脑的DcpS抑制剂，IC50值为 0.069 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Gopalsamy, A., Narayanan, A., Liu, S., et al.Design of potent mRNA decapping scavenger enzyme (DcpS) inhibitors with improved physicochemical properties to investigate the mechanism of therapeutic benefit in spinal muscular atrophy (SMA)J. Med. Chem.60(7),3094-3108(2017)
Van Meerbeke, J.P., Gibbs, R.M., Plasterer, H.L., et al.The DcpS inhibitor RG3039 improves motor function in SMA miceHum. Mol. Genet.22(20),4074-4083(2013)
