α-Galactosylceramide
Cat. No.：YN480220
CAS No. ：158021-47-7
规格
价格(RMB)
库存
| 产品名称: | α-Galactosylceramide |
| CAS No.: | 158021-47-7 |
| Chemical Name: | N-[(1S,2S,3R)-1-[(α-D-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]-hexacosanamide |
| Synonyms: | α-GalCer; KRN7000 |
| 分子量: | 858.34 |
| 分子式: | C₅₀H₉₉NO₉ |
| SMILES: | CCCCCCCCCCCCCCCCCCCCCCCCCC(N[C@@H](CO[C@@H]1[C@@H]([C@H]([C@H]([C@@H](CO)O1)O)O)O)[C@H](O)[C@H](O)CCCCCCCCCCCCCC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | α-Galactosylceramide (α-GalCer) 是一种合成的糖脂，具有抗肿瘤和免疫刺激作用。α-Galactosylceramide 是一种非常有效的NKT细胞激动剂，可与 CD1d 有效结合。α-Galactosylceramide 与 CD1d 的复合物可与NKT细胞的 T 细胞抗原受体结合。 |
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Van Der Vliet, H.J.J., Nishi, N., Koezuka, Y., et al.Effects of α-galactosylceramide (KRN7000), interleukin-12 and interleukin-7 on phenotype and cytokine profile of human Vα24+ Vβ11+ T cellsImmunology98(4),557-563(1999)
Nicol, A., Nieda, M., Koezuka, Y., et al.Human invariant Vα24+ natural killer T cells activated by α-galactosylceramide (KRN7000) have cytotoxic anti-tumour activity through mechanisms distinct from T cells and natural killer cellsImmunology99(2),229-234(2000)
Morita, M., Motoki, K., Akimoto, K., et al.Structure-activity relationship of α-galactosylceramides against B16-bearing miceJ. Med. Chem.38(12),2176-2187(1995)
Nakagawa, R., Motoki, K., Ueno, H., et al.Treatment of hepatic metastasis of the Colon26 adenocarcinoma with an α-galactosylceramide, KRN7000Cancer Res.58(6),1202-1207(1998)
Banchet-Cadeddu, A., Hénon, E., Dauchez, M., et al.The stimulating adventure of KRN 7000Org. Biomol. Chem.9(9),3080-3104(2011)
