BAY-1816032
Cat. No.:YN480232
产品名称: | BAY-1816032 |
CAS No.: | 1891087-61-8 |
Chemical Name: | 2-[3,5-difluoro-4-[[3-[5-methoxy-4-[(3-methoxy-4-pyridinyl)amino]-2-pyrimidinyl]-1H-indazol-1-yl]methyl]phenoxy]-ethanol |
Synonyms: | BAY1816032 |
分子量: | 534.51 |
分子式: | C₂₇H₂₄F₂N₆O₄ |
SMILES: | COC1=C(NC2=NC(C3=NN(CC4=C(F)C=C(OCCO)C=C4F)C5=C3C=CC=C5)=NC=C2OC)C=CN=C1 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | BAY-1816032是有效,有口服活性的苯并咪唑出芽抑制解除同源物蛋白1激酶 (BUB1 (budding uninhibited by benzimidazoles 1) kinase) 抑制剂,IC50值小于 7 nM。 |
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Siemeister, G., Mengel, A., Fernández-Montalván, A.E., et al.Inhibition of BUB1 kinase by BAY 1816032 sensitizes tumor cells toward taxanes, ATR, and PARP inhibitors in vitro and in vivoClin. Cancer Res.25(4),1404-1414(2019)