Orteronel
Cat. No.：YN480271
CAS No. ：566939-85-3
规格
价格(RMB)
库存
| 产品名称: | Orteronel |
| CAS No.: | 566939-85-3 |
| Chemical Name: | 6-[(7S)-6,7-dihydro-7-hydroxy-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthalenecarboxamide |
| Synonyms: | TAK-700 |
| 分子量: | 307.35 |
| 分子式: | C₁₈H₁₇N₃O₂ |
| SMILES: | O=C(C1=CC=C2C=C([C@@]3(O)CCN4C=NC=C43)C=CC2=C1)NC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Orteronel 是一种高度选择性的人17，20-裂解酶 (17,20-lyase) 抑制剂，IC50值为 38 nM，对其选择性是对 11-hydroxylase 和 CYP3A4 的 1000 多倍。 |
| IC50和靶点: | |
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Kaku, T., Hitaka, T., Ojida, A., et al.Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancerBioorg. Med. Chem.19(21),6383-6399(2011)
Yamaoka, M., Hara, T., Hitaka, T., et al.Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeysJ. Steroid. Biochem. Mol. Biol.129(3-5),115-128(2012)
