Eniluracil
Cat. No.：YN480275
CAS No. ：59989-18-3
规格
价格(RMB)
库存
| 产品名称: | Eniluracil |
| CAS No.: | 59989-18-3 |
| Chemical Name: | 5-ethynyl-2,4(1H,3H)-pyrimidinedione |
| Synonyms: | 5-Ethynyluracil; GW776C85 |
| 分子量: | 136.11 |
| 分子式: | C₆H₄N₂O₂ |
| SMILES: | O=C(N1)NC=C(C#C)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Eniluracil (5-Ethynyluracil)，尿嘧啶类似物，一种不可逆的二氢嘧啶脱氢酶(DPD)抑制剂，使 5-FU 的口服生物利用度提高到 100%，促进均匀吸收和可预测的毒性。 |
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Porter, D.J., Chestnut, W.G., Merrill, B.M., et al.Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracilJ. Biol. Chem.267(8),5236-5242(1992)
Baccanari, D.P., Davis, S.T., Knick, V.C., et al.5-Ethynyluracil (776C85): A potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracilProc. Natl. Acad. Sci. USA90(23),11064-11068(1993)
