Furegrelate sodium
Cat. No.：YN480289
CAS No. ：85666-17-7
规格
价格(RMB)
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| 产品名称: | Furegrelate sodium |
| CAS No.: | 85666-17-7 |
| Chemical Name: | 5-(3-pyridinylmethyl)-2-benzofurancarboxylic acid, sodium salt |
| Synonyms: | U-63557A |
| 分子量: | 275.23 |
| 分子式: | C₁₅H₁₀NNaO₃ |
| SMILES: | O=C(C1=CC2=CC(CC3=CC=CN=C3)=CC=C2O1)O[Na] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Furegrelate Sodium (U-63557A) 是一种有效的、口服的、选择性的血栓素合酶 (thromboxane synthase) 抑制剂。Furegrelate Sodium 抑制人血小板微粒体血栓素 A2 (TxA2) 合酶，其 IC50为 15 nM。Furegrelate Sodium 正在开发作为抗血小板药物。 |
| IC50和靶点: | |
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Johnson, R.J., Nidy, E.G., Aiken, J.W., et al.Thromboxane A2 synthase inhibitors. 5-(3-pyridylmethyl)benzofuran-2-carboxylic acidsJ. Med. Chem.29,1461-1468(1986)
Gorman, R.R., Johnson, R.A., Spilman, C.H., et al.Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylateProstaglandins26,325-342(1983)
