Lucerastat
Cat. No.：YN480298
CAS No. ：141206-42-0
规格
价格(RMB)
库存
| 产品名称: | Lucerastat |
| CAS No.: | 141206-42-0 |
| Chemical Name: | 1-butyl-2R-(hydroxymethyl)-3S,4R,5S-piperidinetriol |
| Synonyms: | NB-DGJ; N-(n-Butyl)deoxygalactonojirimycin |
| 分子量: | 219.28 |
| 分子式: | C₁₀H₂₁NO₄ |
| SMILES: | O[C@H]1[C@@H](CO)N(CCCC)C[C@H](O)[C@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lucerasta 是Miglustat 的半乳糖形式，是具有口服活性的葡萄糖酰神经酰胺合成酶(GCS)的抑制剂。Lucerastat 有用于Fabry 疾病研究的潜能。 |
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Platt, F.M., Neises, G.R., Karlsson, G.B., et al.N-Butyldeoxygalactonojirimycin inhibits glycolipid biosynthesis but does not affect N-linked oligosaccharide processingJ. Biol. Chem269(43),27108-27114(1994)
Walden, C.M., Sandhoff, R., Chuang, C.C., et al.Accumulation of glucosylceramide in murine testis, caused by inhibition of β-glucosidase 2: implications for spermatogenesisJ. Biol. Chem.282(45),32655-32664(2007)
Ridley, C.M., Thur, K.E., Shanahan, J., et al.β-Glucosidase 2 (GBA2) activity and imino sugar pharmacologyJ. Biol. Chem.288(36),26052-26066(2013)
Wennekes, T., Meijer, A.J., Groen, A.K., et al.Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilationJ. Med. Chem.53(2),689-698(2010)
Gupta, V., Hild, S.A., Jakkaraj, S.R., et al.N-Butyldeoxygalactonojirimycin induces reversible infertility in male CD ratsInt. J. Mol. Sci.21(1),(2020)
Kasperzyk, J.L., El-Abbadi, M.M., Hauser, E.C., et al.N-butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosisJ. Neurochem.89(3),645-653(2004)
