AY 9944
Cat. No.：YN480327
CAS No. ：366-93-8
规格
价格(RMB)
库存
| 产品名称: | AY 9944 |
| CAS No.: | 366-93-8 |
| Chemical Name: | trans-N1,N4-bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine, dihydrochloride |
| Synonyms: | AY9944;AY 9944,AY-9944 |
| 分子量: | 464.30 |
| 分子式: | C₂₂H₃₀Cl₄N₂ |
| SMILES: | ClC(C=CC=C1)=C1CNC[C@H](CC2)CC[C@@H]2CNCC3=C(C=CC=C3)Cl.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AY 9944 是一种特异的胆固醇生物合成(cholesterol biosynthesis)抑制剂。AY 9944 抑制 7- 脱氢胆固醇 Δ7- 还原酶(DHCR7)酶 (IC50=13 nM)。AY 9944 引起胆固醇不足和 7DHC 积累。在高剂量下，AY 9944 也可在培养的胚胎中抑制固醇 Δ7-Δ8 异构酶，这会导致胆固醇 8-en-3β-ol 的积累。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Horlick, L.Effect of a new inhibitor of cholesterol biosynthesis (AY 9944) on serum and tissue sterols in the ratJ. Lipid Res.7(1),116-121(1966)
Moebius, F.F., Fitzky, B.U., Lee, J.N., et al.Molecular cloning and expression of the human Δ7-sterol reductaseProc. Natl. Acad. Sci. USA95(4),1899-1902(1998)
Lauth, M., Rohnalter, V., Bergström, A., et al.Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levelsMol. Pharmacol.78(3),486-496(2010)
Keller, R.K., Mitchell, D.A., Goulah, C.C., et al.Hepatic isoprenoid metabolism in a rat model of Smith-Lemli-Opitz SyndromeLipids48(3),219-229(2013)
Xu, G., Salen, G., Shefer, S., et al.Reproducing abnormal cholesterol biosynthesis as seen in the Smith-Lemli-Opitz syndrome by inhibiting the conversion of 7-dehydrocholesterol to cholesterol in ratsJ. Clin. Invest.95(1),76-81(1995)
