ML 145
Cat. No.:YN480331
产品名称: | ML 145 |
CAS No.: | 1164500-72-4 |
Chemical Name: | 2-hydroxy-4-[[4-[(5Z)-5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxobutyl]amino]-benzoic acid |
Synonyms: | |
分子量: | 482.57 |
分子式: | C₂₄H₂₂N₂O₅S₂ |
SMILES: | CC(/C=C(S1)/C(N(CCCC(NC2=CC(O)=C(C(O)=O)C=C2)=O)C1=S)=O)=C\C3=CC=CC=C3 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | ML 145 是选择性GPR35/CXCR8拮抗剂,IC50/EC50为 20.1 nM,ML 145 不是相关的 GPR55 孤儿受体。GPR35 由免疫系统的各种细胞来表达,其具有作为炎性疾病的研究靶标的潜力。 |
IC50和靶点: | |
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In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Jenkins, L., Harries, N., Lappin, J.E., et al.Antagonists of GPR35 display high species ortholog selectivity and varying modes of actionJ. Pharmacol. Exp. Ther.343(3),683-695(2012)