A 1120
Cat. No.：YN480333
CAS No. ：1152782-19-8
规格
价格(RMB)
库存
| 产品名称: | A 1120 |
| CAS No.: | 1152782-19-8 |
| Chemical Name: | 2-[[[4-[2-(trifluoromethyl)phenyl]-1-piperidinyl]carbonyl]amino]-benzoic acid |
| Synonyms: | |
| 分子量: | 392.37 |
| 分子式: | C₂₀H₁₉F₃N₂O₃ |
| SMILES: | FC(F)(C1=C(C2CCN(C(NC3=C(C=CC=C3)C(O)=O)=O)CC2)C=CC=C1)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A 1120 是一种高亲和力的视黄醇结合蛋白 4(RBP4)的拮抗剂，Ki值为 8.3 nM，A 1120 破坏了 RBP4 与其结合体转甲状腺素之间的相互作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Montani, A., Wang, Z., Conn, M., et al.Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivoJ. Biol. Chem.284(12),7673-7680(2009)
Dobri, N., Qin, Q., Kong, J., et al.A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesisInvest. Ophthalmol. Vis. Sci.54(1),85-95(2013)
