TMN355
Cat. No.:YN480335
产品名称: | TMN355 |
CAS No.: | 1186372-20-2 |
Chemical Name: | 2-chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluoro-benzamide |
Synonyms: | 2-氯-N-[(9H-芴-9-氨基)羰基]-6-氟苯甲酰胺 |
分子量: | 380.80 |
分子式: | C₂₁H₁₄ClFN₂O₂ |
SMILES: | O=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | TMN355 是有效的化学亲环素 A (cyclophilin A) 抑制剂,可减少泡沫细胞形成和细胞因子分泌。TMN355 可用于动脉粥样硬化。 |
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Ni, S., Yuan, Y., Huang, J., et al.Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approachJ. Med. Chem.52(17),5295-5298(2009)
Gale, T.V., Horton, T.M., Hoffmann, A.R., et al.Host proteins identified in extracellular viral particles as targets for broad-spectrum antiviral inhibitorsJ. Proteome Res.18(1),7-17(2019)