Picrotin
Cat. No.：YN480339
CAS No. ：21416-53-5
规格
价格(RMB)
库存
| 产品名称: | Picrotin |
| CAS No.: | 21416-53-5 |
| Chemical Name: | (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione |
| Synonyms: | 苦亭 |
| 分子量: | 310.30 |
| 分子式: | C₁₅H₁₈O₇ |
| SMILES: | C[C@]([C@@](C1)([C@]2([H])[C@@](C(O)(C)C)([H])[C@@]3([H])OC2=O)O)([C@]3([H])OC4=O)[C@@]54[C@@H]1O5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Picrotin 是甘氨酸受体(GlyRs)的抑制剂,能抑制 α2 GlyR,α1 GlyR 和 α3 GlyR。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Lynch, J.W., Rajendra, S., Barry, P.H., et al.Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiatorJ. Biol. Chem.270(23),13799-13806(1995)
Yang, Z., Cromer, B.A., Harvey, R.J., et al.A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor poreJ. Neurochem.103(2),580-589(2007)
