Clodronate disodium tetrahydrate
Cat. No.：YN480341
CAS No. ：88416-50-6
规格
价格(RMB)
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| 产品名称: | Clodronate disodium tetrahydrate |
| CAS No.: | 88416-50-6 |
| Chemical Name: | P,P'-(dichloromethylene)bis-phosphonic acid, disodium salt, tetrahydrate |
| Synonyms: | Disodium clodronate tetrahydrate |
| 分子量: | 362.93 |
| 分子式: | CH₁₂Cl₂Na₂O₁₀P₂ |
| SMILES: | O=P(C(Cl)(Cl)P(O)(O[Na])=O)(O)O[Na].O.[4] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) 是第一代双膦酸盐，具有抗骨质疏松、抗炎、镇痛作用。Clodronate disodium tetrahydrate 是一种选择性、高效的，可逆、Cl-竞争性的囊泡核苷酸转运体 (VNUT) 阻滞剂，其IC50值为 15.6 nM。Clodronate disodium tetrahydrate 可抑制神经元释放囊泡 ATP，缓解慢性神经病理性疼痛和炎症性疼痛。 |
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Lehenkari, P.P., Kellinsalmi, M., Näpänkangas, J.P., et al.Further insight into mechanism of action of clodronate: Inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metaboliteMol. Pharmacol.61(5),1255-1262(2002)
Sabatino, R., Antonelli, A., Battistelli, S., et al.Macrophage depletion by free bisphosphonates and zoledronate-loaded red blood cellsPLoS One9(6),e101260(2014)
