ABL127
Cat. No.：YN480379
CAS No. ：1073529-41-5
规格
价格(RMB)
库存
| 产品名称: | ABL127 |
| CAS No.: | 1073529-41-5 |
| Chemical Name: | (3R)-3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylic acid, 1,2-dimethyl ester |
| Synonyms: | |
| 分子量: | 332.35 |
| 分子式: | C₁₇H₂₀N₂O₅ |
| SMILES: | O=C(N1N(C(OC)=O)[C@@](C2=CC=CC=C2)(C3CCCC3)C1=O)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ABL127 是一个有选择且共价的蛋白质甲基酯酶 1 (PME-1) 抑制剂，在 HEK293T 和 MDA-MB-231 细胞中的IC50值分别为 6.4 和 4.2 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bachovchin, D.A., Mohr, J.T., Speers, A.E., et al.Academic cross-fertilization by public screening yield a remarkable class of protein phosphatase methylesterase-1 inhibitorsProc. Natl. Acad. Sci. USA108(17),6811-6816(2011)
Pusey, M., Bail, S., Xu, Y., et al.Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor modelsTumour Biol.37(9),11835-11842(2016)
