Ceapin-A7
Cat. No.：YN480387
CAS No. ：2323027-38-7
规格
价格(RMB)
库存
| 产品名称: | Ceapin-A7 |
| CAS No.: | 2323027-38-7 |
| Chemical Name: | N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-3-isoxazolecarboxamide |
| Synonyms: | |
| 分子量: | 470.32 |
| 分子式: | C₂₀H₁₂F₆N₄O₃ |
| SMILES: | O=C(NC1=CN(CC2=CC=C(C(F)(F)F)C=C2C(F)(F)F)N=C1)C3=NOC(C4=CC=CO4)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ceapin-A7 是一种内质网应激ATF6α信号的选择性阻断剂，其IC50值为 0.59 μM。Ceapin-A7 可用于探讨 ATF6α 促细胞活化的机制及其在病理环境中的作用。 |
| IC50和靶点: | |
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Gallagher, C.M., Garri, C., Cain, E.L., et al.Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branchElife5,e11878(2016)
Ma, M., Li, H., Wang, P., et al.ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytesiScience24(7),102791(2021)
Echavarría-Consuegra, L., Cook, G.M., Busnadiego, I., et al.Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infectionPLoS Pathog.17(6),e1009644(2021)
