CE3F4
Cat. No.：YN480390
CAS No. ：143703-25-7
规格
价格(RMB)
库存
| 产品名称: | CE3F4 |
| CAS No.: | 143703-25-7 |
| Chemical Name: | 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde |
| Synonyms: | CE3F4;CE3F4 NEW |
| 分子量: | 351.01 |
| 分子式: | C₁₁H₁₀Br₂FNO |
| SMILES: | O=CN1C(C)CCC2=C1C=C(Br)C(F)=C2Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CE3F4 是一种选择性的Epac1拮抗剂，对 Epac1 和 Epac2(B) 的IC50值分别为 10.7 μM 和 66 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Courilleau, D., Bisserier, M., Jullian, J.C., et al.Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein EpacJ. Biol. Chem.287(53),44192-44202(2012)
Brown, L.M., Rogers, K.E., McCammon, J.A., et al.Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: Structure-function implications for Epac activation and inhibitionJ. Biol. Chem.289(12),8217-8230(2014)
Laurent, A.C., Bisserier, M., Lucas, A., et al.Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophyCardiovasc. Res.105(1),55-64(2015)
Domínguez-Rodríguez, A., Ruiz-Hurtado, G., Sabourin, J., et al.Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat ventricular cardiomyocytesJ. Mol. Cell. Cardiol.87,74-78(2015)
