Apafant
Cat. No.：YN480391
CAS No. ：105219-56-5
规格
价格(RMB)
库存
| 产品名称: | Apafant |
| CAS No.: | 105219-56-5 |
| Chemical Name: | 3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone |
| Synonyms: | 阿帕芬特；阿帕泛；; WEB 2086 |
| 分子量: | 455.96 |
| 分子式: | C₂₂H₂₂ClN₅O₂S |
| SMILES: | O=C(N1CCOCC1)CCC(S2)=CC3=C2N4C(CN=C3C5=CC=CC=C5Cl)=NN=C4C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Apafant (WEB 2086) 是一种有效的血小板活化因子(PAF)拮抗剂，抑制 PAF 结合人 PAF 受体的Ki值为 9.9 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M.Platelet-activating factorJ. Biol. Chem.265(29),17381-17384(1990)
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Kato, M., Imoto, K., Miyake, H., et al.Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigsJ. Pharmacol. Sci.95(4),435-442(2004)
Bielenberg, G.W., Wagener, G., and Beck, T.Infarct reduction by the platelet activating factor antagonist apafant in ratsStroke23(1),98-103(1992)
Cellai, C., Laurenzana, A., Vannucchi, A.M., et al.Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086Br. J. Cancer94(11),1637-1642(2006)
