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α,β-Methylene ATP trisodium

Cat. No.:YN480392

  • CAS No. :1343364-54-4

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    • 产品名称: α,β-Methylene ATP trisodium
      CAS No.: 1343364-54-4
      Chemical Name: 5'-[hydrogen P-[[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate] adenosine, trisodium salt
      Synonyms:
      分子量:571.15
      分子式:C₁₁H₁₅N₅Na₃O₁₂P₃
      SMILES:O[C@@H]([C@H]([C@H](N1C=NC2=C(N=CN=C21)N)O3)O)[C@H]3COP(CP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: α,β-Methylene ATP trisodium 是 ATP 的膦酸酯类似物,是 P2X3 和 P2X7 受体的配体。
      IC50和靶点:
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    • North, R.A.Molecular physiology of P2X receptorsPhysiol. Rev.82(4),1013-1067(2002)

      Coddou, C., Yan, Z., Obsil, T., et al.Activation and regulation of purinergic P2X receptor channelsPharmacol. Rev.63(3),641-683(2011)

      Helms, N., Kowalski, M., Illes, P., et al.Agonist antagonist interactions at the rapidly desensitizing P2X3 receptorPLoS One8(11),1-11(2013)

      Abbracchio, M.P., Burnstock, G., Boeynaems, J.M., et al.International Union of Pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: From molecular mechanisms and pathophysiology to therapyPharmacol. Rev.58(3),281-341(2006)

      Dunn, P.M.Fertility: Purinergic receptors and the male contraceptive pillCurr. Biol.10(8),R305-R307(2000)

      Gibson, K.J., Schubert, K.R., and Switzer, R.L.Binding of the substrates and the allosteric inhibitor adenosine 5'-diphosphate to phosphoribosylpyrophosphate synthetase from Salmonella typhimuriumJ. Biol. Chem.257(5),2391-2396(1982)

      Steegborn, C., Litvin, T.N., Levin, L.R., et al.Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitmentNat. Struct. Mol. Biol.12(1),32-37(2005)

      Krug, F., Parikh, I., Illiano, G., et al.αβ-Methylene-adenosine 5'-triphosphate. A competitive inhibitor of adenylate cyclase in fat and liver cell membranesJ. Biol. Chem.248(4),1203-1206(1973)

      Dessauer, C.W., Scully, T.T., and Gilman, A.G.Interactions of forskolin and ATP with the cytosolic domains of mammalian adenylyl cyclaseJ. Biol. Chem.272(35),22272-22277(1997)

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