N-Desethyl Sunitinib
Cat. No.：YN480399
CAS No. ：356068-97-8
规格
价格(RMB)
库存
| 产品名称: | N-Desethyl Sunitinib |
| CAS No.: | 356068-97-8 |
| Chemical Name: | N-[2-(ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl- 1H-pyrrole-3-carboxamide |
| Synonyms: | N-去乙基-舒尼替尼; SU-12662 |
| 分子量: | 370.42 |
| 分子式: | C₂₀H₂₃FN₄O₂ |
| SMILES: | O=C1NC2=CC=C(F)C=C2/C1=C/C3=C(C)C(C(NCCNCC)=O)=C(C)N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | N-Desethyl Sunitinib (SU-12662) 是 Sunitinib 的代谢物。Sunitinib是有效的，ATP 竞争的VEGFR，PDGFRβ和KIT抑制剂，能够抑制 VEGFR -1，VEGFR -2，VEGFR -3，PDGFRβ 和 KIT 的活性，Ki值分别为 2，9，17，8 和 4 nM。 |
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O'Farrell, A.M., Abrams, T.J., Yuen, H.A., et al.SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivoBlood101(9),3597-3605(2003)
Yu, H., Steeghs, N., Kloth, J.S.L., et al.Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662Br. J. Clin. Pharmacol.79(5),809-819(2015)
