UCPH-101
Cat. No.：YN480412
CAS No. ：1118460-77-7
规格
价格(RMB)
库存
| 产品名称: | UCPH-101 |
| CAS No.: | 1118460-77-7 |
| Chemical Name: | 2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-4H-1-benzopyran-3-carbonitrile |
| Synonyms: | UCPH 101 |
| 分子量: | 422.48 |
| 分子式: | C₂₇H₂₂N₂O₃ |
| SMILES: | O=C(C1)C2=C(OC(N)=C(C#N)C2C3=CC=C(OC)C=C3)CC1C4=CC=CC5=C4C=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UCPH-101 是兴奋性氨基酸转运子亚型 1 (EAAT1) 的抑制剂，其IC50值为 0.66 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Erichsen, M.N., Huynh, T.H.V., Abrahamsen, B., et al.Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)J. Med. Chem.53(19),7180-7191(2010)
Abrahamsen, B., Schneider, N., Erichsen, M.N., et al.Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domainJ. Neurosci.33(3),1068-1087(2013)
Jensen, A.A., Erichsen, M.N., Nielsen, C.W., et al.Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1J. Med. Chem.52(4),912-915(2009)
