Glatiramer acetate
Cat. No.：YN480416
CAS No. ：147245-92-9
规格
价格(RMB)
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| 产品名称: | Glatiramer acetate |
| CAS No.: | 147245-92-9 |
| Chemical Name: | L-glutamic acid, polymer with L-alanine, L-lysine, and L-tyrosine, acetate |
| Synonyms: | |
| 分子量: | 暂无 |
| 分子式: | (C₉H₁₁NO₃.C₆H₁₄N₂O₂.C₅H₉NO₄.C₃H₇NO₂)x.xC₂H₄O₂ |
| SMILES: | OC(CC[C@H](N)C(O)=O)=O.OC([C@@H](N)CC1=CC=C(O)C=C1)=O.OC([C@@H](N)C)=O.NCCCC[C@H](N)C(O)=O.O=C(C)O.[x].[x].[x].[x].[x] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Glatiramer acetate 是髓鞘碱性蛋白的合成类似物和一种免疫调节剂，可用于多发性硬化症的研究。Glatiramer acetate 显示出与 MHC 分子强而杂乱的结合，因此与各种髓鞘抗原竞争，使其呈现给T细胞。Glatiramer acetate 作用的另一个方面是有效地诱导T辅助细胞 2 (Th2) 的特异性抑制细胞迁移到大脑并导致原位旁观者抑制。 |
| IC50和靶点: | |
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Aharoni, R.The mechanism of action of glatiramer acetate in multiple sclerosis and beyondAutoimmun. Rev.12(5),543-553(2013)
Skihar, V., Silva, C., Choinacki, A., et al.Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetateProc. Natl. Acad. Sci. USA106(42),17992-17997(2009)
Aharoni, R., Arnon, R., and Eilam, R.Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitisJ. Neurosci.25(36),8217-8228(2005)
Ziemssen, T., Ashtamker, N., Rubinchik, S., et al.Long-term safety and tolerability of glatiramer acetate 20 mg/ml in the treatment of relapsing forms of multiple sclerosisExpert Opin. Drug Discov.16(2),248-255(2017)
