TNP
Cat. No.：YN480428
CAS No. ：519178-28-0
规格
价格(RMB)
库存
| 产品名称: | TNP |
| CAS No.: | 519178-28-0 |
| Chemical Name: | N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-purine-2,6-diamine |
| Synonyms: | IP3K Inhibitor |
| 分子量: | 443.38 |
| 分子式: | C₂₀H₁₆F₃N₇O₂ |
| SMILES: | FC(C1=CC(CNC2=NC(NCC3=CC=C([N+]([O-])=O)C=C3)=C4N=CNC4=N2)=CC=C1)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TNP是IP6K1和IP3K的抑制剂， 其对IP6K1 和IP3K 的IC50值分别为 0.55 µM 和 10.2 μM。TNP 与两个酶的ATP结合位点结合。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Padmanabhan, U., Dollins, D.E., Fridy, P.C., et al.Characterization of a selective inhibitor of inositol hexakisphosphate kinases: Use in defining biological roles and metabolic relationships of inositol pyrophosphatesJ. Biol. Chem.284(16),10571-10582(2009)
Chang, Y.-T., Choi, G., Bae, Y.-S., et al.Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinaseChembiochem3(9),897-901(2002)
Stokes, A.J., Shimoda, L.M., Lee, J.W., et al.Fcε RI control of Ras via inositol (1,4,5) trisphosphate 3-kinase and inositol tetrakisphosphateCell Signal.18(5),640-651(2006)
