CPYPP
Cat. No.：YN480430
CAS No. ：310460-39-0
规格
价格(RMB)
库存
| 产品名称: | CPYPP |
| CAS No.: | 310460-39-0 |
| Chemical Name: | 4-[3-(2-chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione |
| Synonyms: | |
| 分子量: | 324.76 |
| 分子式: | C₁₈H₁₃ClN₂O₂ |
| SMILES: | O=C(/C1=C\C=C\C2=CC=CC=C2Cl)NN(C3=CC=CC=C3)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CPYPP 是一种DOCK2-Rac1相互作用的抑制剂。CPYPP 结合DOCK2DHR-2结构域，并以剂量依赖性方式抑制DOCK2DHR-2对 Rac1 的鸟嘌呤核苷酸交换因子活性，IC50为 22.8 µM。CPYPP 还抑制DOCK180和DOCK5，对 DOCK9 的抑制活性较少。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Nishikimi, A., Uruno, T., Duan, X., et al.Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2Chem. Biol.19(4),488-497(2012)
Ferrandez, Y., Zhang, W., Peurois, F., et al.Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small moleculeSci. Rep.7(1),14409(2017)
Xu, X., Su, Y., Wu, K., et al.DOCK2 contributes to endotoxemia-induced acute lung injury in mice by activating proinflammatory macrophagesBiochem. Pharmacol.184,114399(2021)
